Field Trial Evaluation of Levofloxacin and Erythropoietin in Treatment of Hemorrhagic Enteritis in Dogs

Enteric fever was a marked problem allover the world in domestic pets and it plays a major role in zoonosis to contact human. The target of our investigation to confirm diagnosis of enteric fever caused by S. paratyphi A using rapid Widal test and isolation and identification of the causative organism. Also the present study was aimed to evaluate clinically and clinicopathologically by a field work-up, the therapeutic value of levofloxacin and human erythropoietin. The present study was carried out on fourteen dogs (9 diseased dogs and 5 apparently healthy dogs). Clinical manifestations were severe watery bloody diarrhea (n.=3), acute diarrhea with occult blood in fecal examination (n.=4), high fever (n.=7), prolonged capillary times (n.=7), enophthalmos (n.=7), loss of skin turgor (n.=7), increased respiratory and pulse rates (n.=7). Clinical examination was revealed abdominal distension (n.=3), hepatomegally (n.=2), abdominal tenderness (n.=7), tympanic sound (n.=7) and increased peristaltic movements (n.=7). Clinical remission of signs occurred after treatment with levofloxacin within 14 days. Widal agglutination test was displayed the titer of 7 positive cases ranged from 1:80-1:320 and 2 negative cases (1:40). Isolation and identification was revealed S. paratyphi A (100%) and S. paratyphi B (22.2%). Significant decreases of PCV %, hemoglobin concentration, erythrocytes and leucocytes count was recorded which was became significant increases after treatment within 8 weeks. Significant increase of ALT activities was denoted hepatic involvement during the infection. Erythropoeitin exerted an excellent therapeutic effect within 48 weeks on basis of erythrogram investigations. It was concluded that combination of levofloxacin and human erythropoietin was the first record for treatment of hemorrhagic enteritis caused by S. paratyphi A in companion dogs in Egypt. (n.= number) [Wael, M. Kelany. Field Trial Evaluation of Levofloxacin and Erythropoietin in Treatment of Hemorrhagic Enteritis in Dogs. Life Science Journal. 2011;8(2):314-322] (ISSN:1097-8135). http://www.lifesciencesite.com.